| 5AM Venture Management, LLC | 3,947,913 | $19.1m | 6.7% |
| BlackRock, Inc. | 3,753,525 | $18.2m | 0.0% |
| Squadron Capital Management LLC | 3,700,000 | $17.9m | 5.6% |
| TWO SIGMA INVESTMENTS, LP | 3,024,936 | $14.7m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,835,669 | $13.8m | 0.0% |
| ACADIAN ASSET MANAGEMENT LLC | 2,681,900 | $13.0m | 0.0% |
| CITADEL ADVISORS LLC | 2,298,403 | $11.1m | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 1,609,078 | $7.8m | 0.0% |
| Opaleye Management Inc. | 1,412,656 | $6.9m | 0.6% |
| ORBIMED ADVISORS LLC | 1,390,576 | $6.7m | 0.1% |
| Decheng Capital LLC | 1,323,327 | $6.4m | 0.9% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,284,117 | $6.2m | 0.0% |
| BANK OF AMERICA CORP /DE/ | 1,114,650 | $5.4m | 0.0% |
| Ishara Investments LP | 1,025,000 | $5.0m | 3.7% |
| PRIMECAP MANAGEMENT CO/CA/ | 957,420 | $4.6m | 0.0% |
| Soleus Capital Management, L.P. | 950,000 | $4.6m | 0.2% |
| STATE STREET CORP | 887,416 | $4.3m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 808,548 | $3.9m | 0.0% |
| Pfizer Inc | 953,834 | $3.9m | 2.3% |
| Connor, Clark & Lunn Investment Management Ltd. | 758,033 | $3.7m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 664,281 | $3.2m | 0.0% |
| ADAR1 Capital Management, LLC | 652,750 | $3.2m | 0.1% |
| MARSHALL WACE, LLP | 591,473 | $2.9m | 0.0% |
| Qube Research & Technologies Ltd | 574,806 | $2.8m | 0.0% |
| D. E. Shaw & Co., Inc. | 546,566 | $2.7m | 0.0% |